Hydroxydiosmin and Diosmin differ in a number of ways, which are compared below:<\/p>\n\n\n\n
Chemical structure and basic information<\/p>\n\n\n\n
Hydroxydiosmin: also known as Hidrosmin, CAS No. 115960-14-0. molecular formula C30H36O16. molecular weight 652.60. it is a compound extracted from the traditional Chinese medicine Citrus aurantium, which can also be obtained by chemical synthesis.<\/p>\n\n\n\n
Diosmin: chemical formula is C28H32O15. molecular weight is 608.545. CAS No. is 520-27-4. It is an organic compound, which is a venous tone-enhancing drug and vasoprotective agent.<\/p>\n\n\n\n
Biological activity and efficacy<\/p>\n\n\n\n
Hydroxydiosmin:<\/p>\n\n\n\n
It has strong antioxidant, anti-inflammatory and anti-angiogenic effects.<\/p>\n\n\n\n
Significant anticancer effect, inhibitory effect on a variety of malignant tumors, such as gastrointestinal tract tumors, colorectal cancer, etc., and may have more potent activity.<\/p>\n\n\n\n
It is well tolerated with relatively few side effects.<\/p>\n\n\n\n
Diosmin:<\/p>\n\n\n\n
Acts primarily as a vasoprotective agent, enhancing venous tone by prolonging the time it takes for epinephrine to act on the vein wall to cause constriction.<\/p>\n\n\n\n
It reduces the permeability of capillaries and enhances their resistance, improves lymphatic return and reduces edema.<\/p>\n\n\n\n
It is widely used in the treatment of various symptoms associated with veno-lymphatic insufficiency, such as leg heaviness, pain, morning soreness and discomfort, as well as various symptoms of acute hemorrhoidal attacks.<\/p>\n\n\n\n
Clinical Applications and Uses<\/p>\n\n\n\n
Hydroxydiosmin: It is mainly used in anticancer therapy, especially for malignant tumors such as gastrointestinal tract tumors and colorectal cancer. In addition, due to its antioxidant and anti-inflammatory effects, it may also be used in the treatment of other diseases requiring these biological activities.<\/p>\n\n\n\n
Diosmin: It is a commonly used drug for the treatment of veno-lymphatic insufficiency and acute hemorrhoidal attacks. It has been widely used in clinical practice with favorable therapeutic results.<\/p>\n\n\n\n
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