Hydroxydiosmin (Hidrosmin) is a derivative of Diosmin, which belongs to a group of semi-synthetic flavonoids with stronger pharmacological activity and better water solubility. The following is a detailed description of Hydroxydiosmin:
1. Basic Information
Chemical name: 5-O-(β-Hydroxyethyl)diosmin (5-O-(β-Hydroxyethyl)diosmin)
CAS No.: 115960-14-0
Molecular Formula: C₃₀H₃₆O₁₆
Molecular weight: 652.597
Properties: yellow to yellow-brown powder
Specification: Common specification is 85% HPLC (High Performance Liquid Chromatography) purity, there are also 98% HPLC purity products.
2. Pharmacological effects
Enhancement of venous tone:
Hydroxydiosmin enhances venous elasticity and reduces venous dilatation and stasis by prolonging the contractile effect of adrenaline on the venous wall.
Improve venous return, reduce lower limb edema and pain.
Improves microcirculation:
Reduce capillary permeability, enhance capillary resistance, and promote tissue fluid return.
Regulate microvascular function, improve blood supply and nutritional metabolism of local tissues.
Promote lymphatic return:
Increase the contraction frequency and drainage speed of lymphatic vessels, reduce tissue edema.
It has a significant alleviating effect on lymphedema.
Anti-inflammatory effect:
Inhibit the generation and release of inflammatory mediators, reduce inflammatory response.
It has therapeutic effect on inflammation caused by chronic venous insufficiency.
3. Clinical application
Venous diseases:
Chronic venous insufficiency: relieve leg heaviness, pain, morning soreness, edema and other symptoms.
Varicose veins: reduce swelling and discomfort caused by varicose veins in lower limbs.
Deep vein thrombosis syndrome: to assist in the treatment of venous dysfunction following deep vein thrombosis.
Lymphatic disorders:
Lymphedema: promotes the return of lymphatic fluid and reduces swelling of the limbs.
Hemorrhoids:
Acute flare-ups: relieve anal moisture, itching, blood in stool, pain and other symptoms caused by hemorrhoidal varicose veins.
4. Advantages
Better water solubility: Hydroxydiosmin has better water solubility than Diosmin, which is easier to be absorbed by the body and requires less dosage when taking.
Stronger therapeutic effect: Hydroxydiosmin shows stronger therapeutic effect in the treatment of edema and varicose vein ulcers.
High safety: As a semi-synthetic drug, hydroxydiosmin has shown good safety and tolerability in clinical application.