Hydroxydiosmin is a synthetic flavonoid that belongs to the derivatives of Diosmin and has enhanced pharmacological activity and clinical applications. Its main applications include:
1. Treatment of chronic venous insufficiency (CVI)
Mechanism of action: Relieving symptoms caused by venous insufficiency, such as leg heaviness, pain, edema, itching and night cramps, by enhancing the tension of vein wall, improving venous return and reducing venous stasis.
Clinical effect: Significantly reduce varicose veins, edema and venous ulcers of the lower limbs and improve the quality of life of patients.
2. Treatment of hemorrhoids
Mechanism of action: reduce congestion and swelling of hemorrhoidal veins, relieve pain, bleeding and itching caused by hemorrhoids.
Clinical effect: It has significant curative effect on acute hemorrhoidal flare-ups and is often used as the first-line drug in hemorrhoidal treatment.
3. Treatment of lymphedema
Mechanism of action: regulating the permeability of microvessels, reducing the leakage of fluid from blood vessels to the surrounding tissues, and at the same time promoting the return of lymph.
Clinical effect: effectively reduce the swelling of limbs caused by impaired lymphatic return and improve the symptoms of lymphedema.
4. Promote postoperative recovery
Mechanism of action: Promote tissue repair and wound healing by improving microcirculation and reducing inflammatory response.
Clinical effect: After surgical operations, especially those involving the venous and lymphatic systems, it helps to reduce postoperative edema and pain and accelerate recovery.
5. Treatment of diseases related to increased capillary permeability
Mechanism of action: Reducing the permeability of capillaries and enhancing the resistance of capillaries.
Clinical effect: Used to treat edema, bleeding and inflammation caused by increased capillary permeability.
6. Auxiliary treatment of thromboembolic diseases
Mechanism of action: Improve venous return, reduce venous stasis and lower the risk of thrombosis.
Clinical effect: In the treatment of lower extremity deep vein thrombosis (DVT), it can be used as an adjunctive drug to reduce symptoms and prevent complications.
7. Improvement of microcirculation disorders
Mechanism of action: Regulating the function of microvessels, improving blood supply and nutritional metabolism of local tissues.
Clinical effect: Used in the treatment of diseases caused by microcirculation disorders, such as diabetic microangiopathy and Raynaud’s disease.
8. Anti-inflammatory effect
Mechanism of action: inhibit the generation and release of inflammatory mediators, reduce inflammatory reaction.
Clinical effect: It has significant therapeutic effect on chronic venous insufficiency and inflammation caused by hemorrhoids.