The mechanism of action of hydroxydeosmin includes the following:
Enhancement of venous tone: Diosmin (Hydroxydiosmin related drug ingredient) enhances venous wall tone, even in hyperthermic states or when the body is acidotic. It has specific affinity for veins without affecting the arterial system. By increasing venous tension, decreasing vascular permeability, and decreasing fluid exudation from the blood, thus reducing tissue edema, it can relieve leg swelling and pain caused by varicose veins in the lower limbs and improve the symptoms of chronic venous insufficiency.
Improvement of microcirculation: Diosmin can significantly reduce the adhesion, migration and disintegration of leukocytes and vascular endothelial cells to release inflammatory substances, such as histamine, bradykinin, complement, leukotrienes, prostaglandins and excessive free radicals, thus reducing the permeability of capillaries and enhancing their tone. It also has the function of reducing blood viscosity and enhancing the flow rate of red blood cells, thus reducing microcirculatory stagnation, and has shown good efficacy in the treatment of inflammatory diseases such as arthritis and allergic rhinitis.
Promote lymphatic reflux: Diosmin increases the speed of lymphatic drainage as well as lymphatic vasoconstriction, thus accelerating the reflux of intertissue fluid, improving lymphatic reflux and reducing edema.
Regulate immune response: Diosmin can regulate the function of immune system, balance the immune response and prevent excessive or insufficient immune response. By regulating the ratio of T-cells and B-cells, it improves the balance of the immune system and shows good immunomodulatory effects in the treatment of autoimmune diseases. Its mechanism of regulating the immune response may be related to affecting the activity of immune cells, and it can regulate the function of immune cells, such as macrophages and T cells, thus suppressing the inflammatory response. It reduces the pro-inflammatory activity of macrophages by inhibiting their differentiation to the M1 phenotype.
Anti-cancer mechanism of action: Hydroxydiosmin is able to regulate the mechanism of programmed cell death, which can inhibit the growth and division of tumor cells, thus achieving the effect of tumor treatment. It also has anti-angiogenic effect, which can prevent the angiogenesis required for tumor cell growth, thus controlling and stopping the growth and spread of tumors.