Hydroxydiosmin and Diosmin differ in a number of ways, which are compared below:
Chemical structure and basic information
Hydroxydiosmin: also known as Hidrosmin, CAS No. 115960-14-0. molecular formula C30H36O16. molecular weight 652.60. it is a compound extracted from the traditional Chinese medicine Citrus aurantium, which can also be obtained by chemical synthesis.
Diosmin: chemical formula is C28H32O15. molecular weight is 608.545. CAS No. is 520-27-4. It is an organic compound, which is a venous tone-enhancing drug and vasoprotective agent.
Biological activity and efficacy
Hydroxydiosmin:
It has strong antioxidant, anti-inflammatory and anti-angiogenic effects.
Significant anticancer effect, inhibitory effect on a variety of malignant tumors, such as gastrointestinal tract tumors, colorectal cancer, etc., and may have more potent activity.
It is well tolerated with relatively few side effects.
Diosmin:
Acts primarily as a vasoprotective agent, enhancing venous tone by prolonging the time it takes for epinephrine to act on the vein wall to cause constriction.
It reduces the permeability of capillaries and enhances their resistance, improves lymphatic return and reduces edema.
It is widely used in the treatment of various symptoms associated with veno-lymphatic insufficiency, such as leg heaviness, pain, morning soreness and discomfort, as well as various symptoms of acute hemorrhoidal attacks.
Clinical Applications and Uses
Hydroxydiosmin: It is mainly used in anticancer therapy, especially for malignant tumors such as gastrointestinal tract tumors and colorectal cancer. In addition, due to its antioxidant and anti-inflammatory effects, it may also be used in the treatment of other diseases requiring these biological activities.
Diosmin: It is a commonly used drug for the treatment of veno-lymphatic insufficiency and acute hemorrhoidal attacks. It has been widely used in clinical practice with favorable therapeutic results.